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The 5C-CPT provides the opportunity to assess both forms of impulsivity within the same task.
No SNPs survived gene-wide corrections for an association with both forms of impulsivity.
Serotonergic and dopaminergic mechanisms were implicated in both forms of impulsivity with a wider range of serotonergic mechanisms (each with a small effect) potentially influencing cognitive impulsivity.
For the 5-HT system, association with synthesis (TPH2) and receptor-mediated mechanisms (HTR1E) may be relevant to both forms of impulsivity.
Further, one might anticipate that arousal levels would be pertinent to both forms of impulsivity under investigation here, but especially the cognitive attention-related form that could be a precursor to the behavioral, aggression-related form.
However nominal significance was shown for genes affecting a range of elements of the 5-HT and DA systems in both forms of impulsivity, and that have previously been reported to be associated with ADHD.
Similar(54)
Checking for the most frequent symptoms in the studied groups indicated that US young adults displaying two or more borderline symptoms were indeed more likely to exhibit the two forms of impulsivity, namely criterion 4 (impulsive self-damaging behaviors, 75%) and criterion 5 (suicidal or self-mutilating behavior, 50%).
To this effect, although these two forms of impulsivity reflect deficits in 'failing to wait', tasks assessing impulsive choice also incorporate a value assessment.
Three tasks measured different forms of impulsivity.
Other forms of impulsivity have also been shown to be independent of IQ (52).
Whether these forms of impulsivity are predictive of or a consequence of obesity is not known.
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Justyna Jupowicz-Kozak
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