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Obviously if these studies were to identify a molecule able to suppress hyperglycemia in an insulin-independent fashion, then, this molecule has the potential to lower hyperglycemia in both forms of diabetes and lengthen lifespan of diabetic people.
The potential of stem cell approaches for diabetes is particularly attractive because the development of both forms of diabetes is dependent upon deficiency of pancreatic beta cells, and the diabetic state can be reversed using beta cell replacement therapy.
A better understanding of the molecular mechanism by which these proteins act could help to design therapeutic strategies to help fight both forms of diabetes.
The symptoms of both forms of diabetes insipidus are similar and include excessive thirst and excretion of large volumes of urine usually 3 to 6 litres each day, although up to 20 litres per day has been recorded.
Both forms of diabetes can lead to heart and kidney disease, nerve damage, and blindness.
Left untreated, both forms of diabetes can cause blindness, kidney failure, hearing loss and lower-limb amputation, as well as increase the risk for heart disease.
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Patients with both major forms of diabetes would benefit from therapies that increase β-cell mass.
We also discuss the potential relevance of insights gained from these approaches for enhancing islet cell survival and function in both major forms of diabetes.
Increased β-cell death coupled with the inability to replicate existing β-cells drives the decline in β-cell mass observed in the progression of both major forms of diabetes.
We conclude that Nkx6.1 is among the very rare factors capable of stimulating beta-cell replication with retention or enhancement of function, properties that may be exploitable for expansion of beta-cell mass in treatment of both major forms of diabetes.
Insulin deficiency underlies both major forms of diabetes.
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