Possibly due to its pivotal role in regulating transcription of genes mediating both adipocyte formation and function (Lehrke and Lazar, 2005), we suggest that PPARγ signaling may be particularly sensitive to interference via the postulated "squelching" mechanism, with deleterious metabolic consequences.
These studies support a central role for glutamatergic synapse formation and function in both disorders and demonstrate that iPSC derived neurons offer a potential system for further evaluation of processes leading to synaptic dysregulation and for the design and screening of future therapies.
The newly identified Nde1 partners cohesin and SNF2h are both known to participate in heterochromatin formation and function in multiple tissues.
In addition to inborn errors of thyroid metabolism and acquired thyroid disorders, more recently, distinct genetic entities affecting normal formation and function of both brain and thyroid have been recognized.
However, taken alone, the identification of the A3AR as a mediator of both neutrophil chemotaxis and of cytoneme formation and function makes the receptor a potentially important therapeutic target by which to modulate neutrophil function in immunological and inflammatory disorders or infectious diseases.
Both ROS and Nox proteins are essential for formation and function of invadopodia, inducing ECM degradation and cell invasiveness.
Formation and function of myofibroblasts is dependent on both molecular factors and the local mechanical environment.
Depletion of the protein causes aberrations in spindle formation and function – with defects in the anaphase movement of both the large "housekeeping" chromosomes and the numerous specialised minichromosomes.
Biomaterial scaffolds must provide the 4Fs for regenerative medicine: Form, Fixation, Formation, and Function.
