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For questions involving drug risks and safety, it is the adverse effects profile that will guide the choice of study design, both for identification of the effect (signal) and assessment of causation.
The numbers were used both for identification of gene groups for each class, and for calculation of correlation coefficients.
The recent bioterrorism-associated anthrax outbreak demonstrated the need for sensitive, specific, and rapid methods for diagnosis and confirmation of anthrax, both for identification of suspect B. anthracis isolates and direct detection of B. anthracis DNA in clinical specimens.
Future studies should also employ newer technologies and strategies such as large-scale multigene association studies, gene expression studies [ 9], and biomarker/proteomic technologies [ 10] both for identification of novel candidate genes and to provide additional data that support the relevance of reported associations.
Considering the central role that serum plays in clinical diagnostics, the characterization of 2-DE gel serum sheep protein profiles increases the tools available for ovine medicine, both for identification of new disease markers, and for improved understanding of the physiological and pathological functions of proteins in diseased and healthy sheep.
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This paper describes the design and implementation of an indirect adaptive controller that uses neural networks both for identification and control of an experimental pilot distillation column containing a mixture of ethanol and water.
The main correlation between the two assays, microarrays and quantitative RT-PCR, was high for all genes, indicating a good agreement between both assays for identification of deregulated genes.
Both algorithms for identification of least strongly responding expression levels, GeNorm and Normfinder, produced very similar results, but disagreed in some points (cf. tab. 2).
Gel electrophoresis of the amplification products demonstrated high specificity of both primer pairs for identification of relevant species.
QconCAT-derived proteins are labelled with heavy isotopes and serve both as markers for identification of the similar unlabeled proteins and a scale for their quantification [ 65].
The collection of samples for screening, the usefulness and cost/benefit ratio of which remain open to debate [ 11, 22], is indispensable both for the identification of colonised/infected patients and carriers and for the prevention of secondary infections in carriers [ 25].
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