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Nevertheless, these data suggest that APPL1 and APPL2 are both essential regulators of the DNA damage survival and repair response and that loss of one protein cannot be fully compensated by the other.
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Together, these data show that the genome-wide binding of BRA in endoderm progenitors broadly overlaps with that of EOMES and SMAD2/3, both of which are essential regulators of endoderm formation.
Sex steroids are essential regulators of both reproductive function and energy metabolism, whereas their imbalance causes infertility, obesity, glucose intolerance, dyslipidemia, and increased appetite.
Dendritic cells (DC) are essential regulators of both innate and acquired arms of the immune system [ 2].
It has been recently shown that both Acer and Ace2 are essential regulators of heart function [ 43].
It is also known that both PKA and Sch9 are essential regulators of Polymerase III-dependent transcription [ 27, 37].
Microtubules are essential regulators of cell polarity, architecture and motility.
Small non-coding RNAs are essential regulators of gene expression at the transcriptional and posttranscriptional levels.
CDKs are valid targets as they function as essential regulators of cell growth and differentiation.
These studies provide a framework for studying crypt morphogenesis and identify essential regulators of niche formation.
Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com