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Adrenomedullin inhibits apoptosis of both endothelial and tumour cells.
Combining AZD2171 and gefitinib could potentially provide inhibitory effects on both endothelial and tumour cells.
Signalling pathways mediated by VEGFRs in both endothelial and tumour cells are now being delineated.
Altogether, our results showed that NaPaC inhibited the A431 tumour growth acting on both endothelial and tumour cells.
To summarise, ZD6474 exerts significant antitumour effects in an intracerebral glioma model with effects on both endothelial and tumour cells.
While low expression of both endothelial and tumour cell FAK associated with luminal A tumours, only endothelial-FAK was independently associated with these tumours in multivariate analysis.
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These observations suggest that an antiangiogenic and targeted therapy against both endothelial cells and tumour cells may inhibit brain tumour growth by disrupting the vascular endothelial microenvironment, in addition to abrogate the EGFR activation.
Cathepsins are produced by both endothelial cells and tumour cells and these proteases are activated by the acidic pH that is found in the surroundings of tumours.
Whereas cetuximab seems to affect the tumour cells directly, by abrogating EGFR activation, nimotuzumab would target both endothelial cells and tumour cells through a significant anti-angiogenic activity.
It has recently been shown that hypoxia is able to suppress the pro-apoptotic effects of serum deprivation on both endothelial cells and tumour cells via induction of VEGF [ 16, 17].
Putative TEMs are genes that were both endothelial and preferentially expressed in tumours.
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both endothelial and macrophage
both endothelial and epithelial
both iatrogenic and tumour
both oncogenic and tumour
both endothelial and hamatopoetic
both endothelial and smooth
both normal and tumour
both endothelial and uterine
both endothelial and mesenchymal
both healthy and tumour
both biological and tumour
both intravascular and tumour
both endothelial and cardiac
both endothelial and platelet-derived
both endothelial and metastatic
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