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Nanoparticles were recently reported to be able to improve both efficiency and specificity in polymerase chain reaction (PCR).
Alternative processing of hairpin transcripts by different RNA nucleases is shown in Figure 3. Optimization of the terminal asymmetry in siRNA duplexes increases both efficiency and specificity of silencing because it preferentially enhances entry of the guidance strand instead of the passenger strand, into RISC.
So the question is how to achieve both efficiency and specificity and as a byproduct have changeability.
Our data clearly demonstrate both efficiency and specificity of DEP-1 ASO treatment, since expression of DEP-1 was reduced while gene expression of other insulin signaling components was unchanged (PTP1B, insulin receptor) in epididymal tissue, skeletal muscle, and liver.
Proteins involved in cAMP signaling, such as GPCRs, adenylyl cyclases and cAMP effectors such as the cAMP-dependent protein kinase (PKA) and its downstream targets, are organized into physically and functionally distinct multi-protein complexes, an arrangement that increases both efficiency and specificity of signaling.
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The efficiency and specificity was also verified by assaying protein expression of each gene.
The polyclonal antibody against HCCR protein, prepared by immunizing Bclb/c mice with the purified recombinant protein pMBPc-HCCR-His, had both high efficiency and specificity which were tested by indirect ELISA (Antibody titer: 1 10000) and Western blot.
By projecting quantum chemical similarities onto orthogonal (independent) factors, it was possible to uncover parameters of both binding Efficiency and Specificity to open new perspectives on the molecular properties of auxins.
In support of the co-evolutionary hypothesis as a mean to fix innovative mutations in the RbcL subunit, previous research has shown that when multiple amino acid replacements are introduced, significant changes can occur in both enzyme catalytic efficiency and specificity [ 64].
Directed mutagenesis of Rubisco residues in Chlamydomonas showed that a single amino acid substitution, apart from the active site, has little effect on Rubisco function even if it occurs in a functionally important region, but when double or triple substitutions were created, significant changes were observed in both enzyme catalytic efficiency and specificity [ 1, 22, 26, 27].
Nonetheless, our system is unique in that it utilizes the biomimetic combination of cell rolling and multivalent binding, achieving high capture efficiency and specificity from both cell suspensions and human blood.
More suggestions(16)
both efficiency and resilience
both efficiency and capability
both efficiency and income
both efficiency and reliability
both efficiency and non-iteration
both efficiency and conservation
both coverage and specificity
both volatility and specificity
both efficiency and competition
both efficiency and fairness
both efficiency and profitability
both efficiency and performance
both efficiency and effectiveness
both efficiency and flexibility
both efficiency and robustness
both efficiency and cost
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com