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In the absence of both dysfunctions, this aspect cannot be guaranteed.
The final common pathway of both dysfunctions is a heightened cortical response to repeated stimuli, i.e. a lack of habituation.
For this MIC, 600 mg q8h guarantees high PST in all patients and increases the probability of Cmin> 2. For MGP with MIC of 2, only in the presence of both dysfunctions is possible achieving the PK/PD target.
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Both dysfunction of calcium signaling and increased ER stress have been linked to ALS-associated neurodegeneration at early stages (Lee et al., 2016; Woehlbier et al., 2016).
Accordingly, both dysfunction and misregulation are possible effects of developmental immunotoxicity (Dietert 2008).
Although the exact mechanism is unclear, higher maternal blood pressure could be a feature shared by both endothelial dysfunction and placental dysfunction, as both entities are not mutually exclusive [ 28].
The etiology of both of these conditions has been thought to be based on both hepatic dysfunction and hypoperfusion.
Parkinson's disease patients are prone to dry eye due to both autonomic dysfunction and motor symptoms affecting blinking.
Both cognitive dysfunction and AEP-characteristics might be related to reduced glutamatergic neurotransmission as induced by glutamate-antagonist like ketamine.
Endothelial activation alters vascular tone and induces both microcirculatory dysfunction and coagulopathy, which will in turn favor ischemic and/or hemorrhagic lesions [34].
Recent studies suggest that both executive dysfunction and personality traits combine with symptoms to affect the social outcome of persons with schizophrenia.
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