Its expression is regulated both temporally and spatially during neural development [19], [30], [31].
They determined that insertions are far more common in our nearest taxonomic cousins than in us, both in heritable ways and during neural development.
There is increasing evidence that ATP-dependent chromatin remodeling complexes based on the alternative DNA-dependent ATPases, Brg1 and Brm, plays essential roles during neural development in both vertebrates and invertebrates.
Both proteins, shox2 and isl1, are highly expressed during neural development and isl1 plays an important role during differentiation of neurons in the brain.
The agonism of the serotonin system during neural development of birds genetically predisposed to aggression alters both the dopaminergic and serotonergic systems further increasing their aggressiveness.
Furthermore, miR-184 results in an interesting MeCP2 target as it has been shown that this miRNA plays a role during neural development by inducing proliferation and inhibiting both neuronal and astrocytic differentiation (Liu et al., 2010).
The lack of complete penetrance of this phenotype, suggests that the absence of p53 in these mice can be partially compensated for by other genes, for instance by the p53 family members p63 and p73, both of which have been shown to play important roles during neural development (Quadrato and Di Giovanni, 2012).
Cell adhesion molecules of the Immunoglobulin superfamily (IgCAMs) play diverse functions during neural development.
What is going wrong during neural development that leads to these disorders?
If this is, indeed, why they are unsilenced during neural development, then our brains can be thought of as hosting a kind of evolution in miniature.
