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At week 76, the reductions in DBP with empagliflozin 10 mg and 25 mg were not significantly different compared with placebo, but a significant decrease was noted for both doses when compared with sitagliptin (Table 2).
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Compound 4f showed the highest anti-inflammatory activity (% edema inhibition = 15 20%) at all doses when compared to reference drug celecoxib (% edema inhibition = 15.7 17.5%).
Afucosylated therapeutic antibodies with enhanced ADCC activity have been reported to possess greater efficacy in tumor growth inhibition at lower doses when compared to fucosylated therapeutic antibodies.
In paediatric PAH patients, nondose-proportional pharmacokinetics of bosentan occur at lower doses when compared with healthy adult subjects.
Zebrafish growth increased in some experimental days in response to low PCB 31 doses when compared with control zebrafish values.
There were no statistically significant differences observed at the other clinical doses when compared with controls (100 ± 1.6%).
The weights of infected liver and spleen also gradually decreased with increase in drug doses when compared with infected controls, although the difference was not significant.
Also, please note that the experiments in current Figure 4 figure supplement 3 applied lower irradiation doses when compared to original Figure 3A (now Figure 4B).
Cohen & Arnold (2011) note that DNA-reactive carcinogens produce "strikingly non-linear dose response" curves, due in part to an acceleration of damage, or lack of repair at higher doses when compared to lower doses.
The mean level of creatinine for all the drug doses was found to be similar with a small but insignificant increase in urea levels at 7.5 mg/kg single and double doses when compared to untreated controls.
Weight loss was achieved in all participants receiving liraglutide, compared with a 1.0 kg weight gain observed in those receiving glimepiride (P < 0.0001 for all liraglutide doses when compared with glimepiride).
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