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At least 95% of the subjects in each group received both doses of study vaccine/placebo (609 subjects received 2 doses; 27 subjects received only 1 dose [8, 10, and 9 subjects in the F17, F19, and placebo groups, respectively]).
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Of the 216 participants, 106/108 adults and 106/108 children received both doses of the assigned study agent and provided all three blood samples.
A reduction in the proinsulin-to-insulin ratio toward more physiological proportions was observed with both doses of exenatide in the study reported by Buse et al. (46), whereas a significant reduction in this ratio was only observed with the 10-μg exenatide dose in the trial reported by DeFronzo et al. (47).
At the end of the study, both doses of 5-Loxin® conferred clinically and statistically significant improvements in pain scores and physical function scores in OA patients.
Both doses of curcumin examined in this study were able to decrease superoxide production by almost two-fold.
In a different study, both doses of milnacipran (100 and 200 mg/day) were associated with significant improvements in pain and other symptoms [ 62].
Three doses of study or control (rabies) vaccines were administered intramuscularly at 1 month intervals.
All doses of study drugs will be supervised.
Analyses of bleeding were performed in patients who received 1 or more doses of study drug.
aThe total number of subjects who received at least 3 doses of study drug.
Overall, 98.7% of the enrolled subjects received 3 doses of study vaccine.
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