Your English writing platform
Discover LudwigSuggestions(4)
Exact(2)
The reduction in both dopamine levels and D1 receptor expression might have caused a compensatory modification of the downstream signaling.
Studies determined both dopamine levels and dopamine receptor gene polymorphisms and FMS [ 9, 10, 22, 23].
Similar(58)
Prior preclinical and clinical work has demonstrated an inverted U-shaped relation between brain dopamine levels and cognition [ 58],[ 59], such that both excessive and insufficient dopamine levels impair cognitive performance.
While the pathophysiology is unclear, decreased dopamine levels and dopamine dysregulation are hypothesized to play a role.
However, in iron-restricted mice, striatal dopamine levels and motor behavior were unchanged compared to saline-treated mice.
Nevertheless, all drugs of abuse increase dopamine levels and, thereby, activity at the dopamine receptors.
Intrastriatal transplantation of foetal dopamine neurons in affected individuals aims to normalize dopamine levels and release of dopamine in striatum.
While methylphenidate and l-Deprenyl correct both striatal dopamine levels on PET imaging and defective attention system function in Nf1 mutant mice, pharmacologic agents that target de-regulated cyclic AMP and RAS signaling in these mice do not.
When dopamine-producing (dopaminergic) neurons are damaged or destroyed, dopamine levels drop and the normal signaling system is disrupted.
We recognize that atomoxetine can increase extracellular dopamine levels (59) and our patients took levodopa and/or dopamine agonists.
n-butylidenephthalide, in particular, had the greatest neuroprotective capacity and was shown to also restore food-sensing behaviour and dopamine levels in both pharmacological and transgenic C. elegans PD models as well as enhancing the life span of 6-OHDA-treated animals [58].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com