Sentence examples for both discovery and replication from inspiring English sources
40345_2017_101_MOESM1_ESM.docx Additional file 1. Detailed prediction results in both discovery and replication cohorts.
The overall sample size in both discovery and replication cohorts were small and therefore our results should be regarded as preliminary.
Significant evidence of replication was observed, and both SNP markers surpassed the formal threshold for genome-wide significance upon meta-analysis of both discovery and replication stages (P = 5.79 × 10 -10 10 -10allele odds ratio (OR) = 1.26 for rs13382811 and P = 2.01 × 10(-9), per-allele Oratio.79 fOR rs6469937).
A multi-step quality control (QC) strategy was employed for the samples and SNPs using the following strategy for both discovery and replication cohorts.
The relative distributions of DRB1*1501 genotype frequencies among the respective control and IPF subpopulations were also similar in both discovery and replication cohorts (Table 3).
Both discovery and replication studies need consecutive cohorts of hip replacement patients.
39 As by the time of the GWAS publication in December 2012 5 both the discovery and replication genotypes of the current study were completed, PTPN22 and TNIP1 were not included in the current study as candidate genes.
After performing the meta-analysis of the two SNPs tested in both the discovery and replication datasets, the statistical significance of the association of both IL6R markers with joint damage was found to increase (P = 0.00011 and P = 0.0021 for rs4845618 and rs4845374, respectively) (Table 1).
One limitation of this study was the modest size of both the discovery and replication samples.
The four population clusters (C3 C6) with at least 50 probands in both the discovery and replication sample sets were considered for the replication study (Supplementary Table 6).
Methylation was measured in both the discovery and replication pair sets following removal of MTX-exposed pairs 1, 4, 10, 13, and 19 (Additional file 1: Table S2).
