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The use of locus specific primers ensured both directionality and specificity of the walks, alleviating the generation of spurious amplicons, typically observed in randomly primed walking protocols.
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More generally, how do cis and trans interactions, together with Fringe proteins, specify a particular set of signaling states, and how do those states determine the directionality and specificity of signaling?
Understanding what signaling states are possible, how expression levels of various pathway components determine those signaling states, and how cells in different signaling states interact with one another, could provide a useful way to think about the Notch signaling system more generally and to infer the directionality and specificity of signaling in more complex contexts.
Analysis of the ARU data allows for identification of the important topological components of the crystal structure in terms of both directionality and dimension.
Locatedness in the strong sense specifies an address for the sound, e.g., by specifying both directionality and distance from the hearer (thus including egocentrical directionality as a component), or by locating sounds in allocentric space (e.g. a siren from the boat at Pier 3).
Consequently, spatial separation of promoter and 5′ splice sites might directly impact both directionality and transcription accuracy.
This figure demonstrates both directionality and magnitude of the relationships between SI or TLV for HAL and psychosocial factors.
Values for both directionality and the percentage of variance (R) explained for each trait are given in Table 2. ST and SJK performed genotyping.
If only preoperative patients are considered, both sensitivity and specificity increase to 100%.
Both sensitivity and specificity of CA-125 were better in postmenopausal than in premenopausal women.
Both sensitivity and specificity showed large variability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com