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Programmed cell death, or apoptosis, is central for both development and tissue homeostasis of metazoans.
BMP signalling is also complex and pleiotropic with wide ranging roles outside the vasculature in both development and tissue repair.
DOI: http://dx.doi.org/10.7554/eLife.04876.002 Mechanical factors are known to play crucial roles in both development and tissue regeneration from stem cells.
However, SPARC has also been shown to be secreted by non-epithelial cells in non-ossifying tissues (Sage et al., 1984) during both development and tissue repair, where it mediates ECM remodeling and turnover, and cell-ECM interactions (Engel et al., 1987; Sage et al., 1989; Funk and Sage, 1991; Lane and Sage, 1994; Murphy-Ullrich et al., 1995; Chlenski and Cohn, 2010).
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During epithelial stratification, hCLCa2 expression level increases, suggesting a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation [57], [59].
The cytoskeletal adaptor protein vinculin plays a fundamental role in cell contact regulation and affects central aspects of cell motility, which are essential to both embryonal development and tissue homeostasis.
Over the last two decades, fibroblast growth factors (FGFs) and their receptors (FGFRs) have stood up as major players in both embryonic development and tissue repair.
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional factor involved both in development and tissue repair, as well as pathological processes such as cancer and metastasis.
In vertebrates, Wnt signaling starts during development and acts by programing and regulating cell proliferation, differentiation, translocation, polarization, and fate decisions, during both embryonic development and tissue homoeostasis in the mature individual [ 1, 2].
The balance between cell division and cell death is very important to coordinate normal cell turnover in both development and maintenance of tissue homeostasis in multicellular organisms [ 1].
Crucially, 6meAs are dynamically regulated, both in terms of development and tissue specificity.
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