Among these are the regulation of nervous system during both development and injury repair [23], [24], multiple roles in the immune system [25], [26], adipocytes [27], endothelium [28], [29], and chondrocytes and bones [30] [32].
BMP signalling is also complex and pleiotropic with wide ranging roles outside the vasculature in both development and tissue repair.
However, SPARC has also been shown to be secreted by non-epithelial cells in non-ossifying tissues (Sage et al., 1984) during both development and tissue repair, where it mediates ECM remodeling and turnover, and cell-ECM interactions (Engel et al., 1987; Sage et al., 1989; Funk and Sage, 1991; Lane and Sage, 1994; Murphy-Ullrich et al., 1995; Chlenski and Cohn, 2010).
In addition to developing ex vivo skin sheets for the treatment of burns victims, such cultures have also been used as a means of investigating both the development and repair of the epidermis, in more relevant conditions than simple 2-D culture, but without the use of animals.
In addition to developing ex vivo skin sheets for the treatment of burns victims, such cultures have also been used as a means of investigating both the development and repair of the epidermis, in more relevant conditions than simple two-dimensional culture, but without the use of animals.
Also, MMP-2/9 has an important extracellular matrix homeostatic function during muscle growth, development and repair processes.
Angiogenesis is an important biological process in tissue development and repair.
These have mainly focused on vascularization during the development and repair of bone.
Growth and differentiation factor-5 (GDF-5) is a multifunctional protein that regulates the development and repair in many tissues.
