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The high-density SNP coverage of the genome that is essential to provide sufficient LD for detecting epistasis is not available in most GWAS cohorts genotyped with older, relatively low-density SNP chips (21– 24), posing difficulties to both detection and replication of epistatic signals.
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Gene Ontology categories that had p-values less than or equal to 0.05 in both the detection and replication datasets were considered replicated and carried forward for presentation and discussion.
Another hurdle for studying epistasis is the relatively small sample size in many existing GWA cohorts that may limit the power of detection and replication of epistasis signals unless the epistatic effects to be detected are large.
The second, 'Actin Cytoskeleton', a GO Cellular Component, had p-values of 0.040 and 0.046 in the detection and replication studies, respectively.
P-values were derived from the two null distributions for every MDR model in the detection and replication data sets.
The first, 'Regulation of Cellular Component Organization and Biogenesis', a GO Biological Process, had p-values of 0.010 and 0.014 in the detection and replication studies, respectively.
Colonoscopy permits both detection and removal of these dangerous lesions.
HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc detection indicated expression and replication of this HBV genome in mice, similar to other HBV isolates.
In the above example, for the detection of spoofing attacks and replication attacks where attackers take on duplicate identities, node A will test the following condition.
However, monocytes have been implicated as a viral reservoir during HIV infection based on the detection and recovery of replication-competent virus from circulating monocytes isolated from HIV-positive individuals [ 20, 25, 26].
Rif1 loss affects both number and replication-timing specificity of the interactions between replication-timing domains.
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CEO of Professional Science Editing for Scientists @ prosciediting.com