Produced and promoted by a strange collection of rightwing Christian evangelicals and exiled Egyptian Copts, the trailer was created with the intention of both destabilizing post-Mubarak Egypt and roiling the US presidential election.
Marina Alberti, a professor of urban design at the University of Washington, in Seattle, has described cities as "hybrid ecosystems" where nature is both destabilized by and reacting to human influence.
Both are despotic; both destabilize their neighbors.
RanBP1 accomplishes this by both destabilizing the outward and stabilizing the inward conformations.
Hence the absence of autophagy causes a vast accumulation of both destabilizing the cell.
Taken together, iron and heme excess may negatively regulate p53 signaling in the afflicted cells through both destabilizing p53 protein and interfering with its binding to the target DNA.
Thus, we suggest that Tah18's pro-death function in yeast is promoted by oxidative stress both by destabilizing its interaction with Dre2 and allowing its efficient targeting to the mitochondria.
Loss of metal and disruption of quaternary structure thus promote improper association both by destabilizing the protein and making higher energy conformations thermally accessible and by exposing regions of the protein most prone to forming these intermolecular interactions.
Both mutations destabilize the coiled coil conformation at neutral pH and increase the pKa of the formerly ion-paired Glu side-chain, verifying the formation of a salt bridge even in the case where a charged side-chain is destabilizing.
Outside observers are terrified about Italy's election, and rightly so: even if the nightmare of a Berlusconi return to power fails to materialize, a strong showing by Mr. Berlusconi, Mr. Grillo, or both would destabilize not just Italy but Europe as a whole.
