With respect to cannabinoids, it was recently reported that CBD and tetrahydrocannabivarin both act as TRPV3 agonists, whereas cannabigerovarin and cannabigerolic acid can both desensitize TRPV3 (Table 1).
β-Arrestin-mediated scaffolding of PDE often accompanies GPCR activation, and is an important mechanism whereby GPCRs are both desensitized and internalized.
Of course, that much exposure to one another naked often led to some shenanigans later on, but by that point, we were both sufficiently desensitized to any worries or discomforts about our bodies that we were able to purely focus on one another.
Sexualized, demeaning behavior desensitizes both perpetrators and victims, often to the point of overlooking or downplaying red flags that are precursors to sexual assault.
"My concern about the rise of pornography--or the rise in its ease of access, especially online--is that it desensitizes both boys and girls, it makes serious activities casual and thereby serious relationships casual, and it rushes kids into matters that need maturity, if not adulthood.
Desensitized to desensitization?
Capsaicin treatment couples the unique ability of the drug to first activate, and, subsequently, upon repeated administration, desensitize both the afferent pathway that from channel activation conveys nociceptive signals, and the 'efferent' function that results in sensory neuropeptide release [48].
Like other well-characterized chemesthetic agents [14] [22], repeated application of IBA resulted in both sensitizing and desensitizing patterns of sensation and the evoked pattern was shown to be dependent upon the interstimulus interval.
As stated above, the rise time of currents evoked by saturating concentrations of GABA may depend on both opening/closing and desensitized state(s) but a direct estimation of contributions of these conformational transitions is not straightforward.
By desensitizing both β1- and β2ARs, i.e. terminating their G protein-mediated signaling through cAMP, it dramatically reduces cardiac inotropic and adrenergic reserves, and since it is markedly elevated in HF, its blockade represents an attractive therapeutic strategy for heart disease treatment [ 8- 11, 31- 35].
