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It has been the reference standard medication for acute and prophylactic treatment of bipolar disorder/manic depressive illness, a brain disorder in which normal moods alternate with both depression and mania, which is recognized by the World Health Organization as a leading debilitating neuropsychiatric disorder that affects about 1.3% of both sexes globally [ 1].
Both depression and mania were also associated with subjective assessments of sleep.
Lithium (Li) is a relevant mood stabilizer metal for the treatment of bipolar disorder (BD), as it protects from both depression and mania and reduces the risk of suicide.
Additionally, peaks in mania are often observed in May or June, and both depression and mania sometimes express secondary peaks in the fall.
It appeared to be difficult to assess by patients because its extreme points (distractibility for mania and loss of attention for depression) were difficult to differentiate clinically and are potentially disturbed in both depression and mania.
These competing processes promoting possible increased or decreased melatonin masking of EYA3 in the Spring might produce the paradoxical peaks of both depression and mania at about the same season, depending on various factors influencing susceptibility in a diverse population.
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As its outmoded moniker suggests, patients experience periods of both deep depression and mania, an extremely hyperactive state that can lead to wild spending, risk-taking, and extreme sexual activity.
Our findings suggest that both symptoms of depression and mania fall into two separate groupings.
In Huntington's Disease, both depression [65] and mania [66] are commonly reported.
Background: Bipolar disorder (BPD) is a mental illness in which depression and mania typically alternate, and both phases can present with psychotic features.
In order to differentiate between depression and mania, symptoms that are common to both mania and depression, or difficult to distinguish in a self-report format, were excluded from the assessment instrument (concentration difficulties, decreased sleep and alterations in appetite).
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