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Both data sets suggested that the combination reversed the down-regulation of the expression of genes related to innate immune responses observed with CPT-11 treatment.
Visual inspection of the quartile ranges in both data sets suggested that the highest pain intensity reports of the experimental group (50th percentile and greater) overlapped with the lowest pain reports (50th percentile or lower) of the patients seeking intervention for their back pain - 16 to 68 mm, and 0 to 50 mm respectively.
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The data presented here are complementary to those obtained using BACFA analysis in that both data sets suggest a scenario where H37Rv is better equipped to adapt to intracellular environments.
The corresponding regression for genes outside of the aberrations is nearly horizontal for both data sets, suggesting that the observed correlations are not a product of a bias in the expression data.
The majority of the cDNAs that were significantly differentially expressed were assigned to the same group in both data sets suggesting a minimal impact of the false positive and negative errors in this study.
The fact that this is observed in both data sets suggests that it may not be a chance finding (although chance cannot be entirely discounted), the explanation for which is not clear to us.
The recovery of an eocyte tree, rather than the three domains tree, from both data sets suggests that this result is robust to the choice of genes, alignment methods, or masking protocols.
In general, a few highly connected 'hub' genes, some with known subtype-specific involvement appear to hold together components of these networks for both data sets, suggesting their central roles in these subtypes.
The STRUCTURE output for both SSR and AFLP data sets suggested the existence of two clusters.
Although a few neuroanatomical and developmental characters were later proposed as putative novelties of Paradoxopoda10,11, subsequent exploration of molecular data sets suggested that this grouping is a long-branch artefact3,12.
While the viromes of wild-caught Ae. aegypti from Cairns and Bangkok were surprisingly similar, analyses of other available RNA-Seq data sets suggested that the levels of major ISVs in laboratory reared mosquitoes may be different.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com