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The activation energy and molecular dipole moment increase with increasing chain length for both cyclic and linear molecular types.
The Asn Gly Arg (NGR) motif in both cyclic and linear form has previously been shown to specifically bind to CD13/aminopeptidase N that is selectively overexpressed in tumor vasculature and some tumor cells.
Using data from c-AMP assays in combination with structural analysis of melanocortin receptor/ligand models, we conclude that a lysine residue at the C-terminus of the His-Phe-Arg-Trp core sequence of melanocortin hormone is an important determinant for receptor selectivity in the both cyclic and linear MSH analogues.
Both cyclic and linear peptides were identified, and the KDM1 and -4 binding phages did not share any sequence motifs.
Here we show VvCCD1, VvCCD4a and VvCCD4b are capable of catalysis of the cleavage of C40 carotenoid substrates at the 9, 10 (9', 10') (ζ-carotene, β-carotene and/or ϵ-carotene) and lycopene at the 5, 6 (5', 6') double bond position to release the corresponding C13 apocarotenoid products (Table 1 and Figure 6), confirming cleavage of both cyclic and linear substrates.
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Affinity for CD13+ cancer cells was similarly improved 10-fold for both the cyclic and linear NGR when presented in a multivalent fashion on the surface of an LTSL.
Both cyclic voltammetry and linear voltammetry were performed in the three solutions at three temperatures (25, 50 and 80 °C) and under ultrasonic conditions (F = 20 kHz, PT = 5.8 W) to calculate the mass transfer diffusion coefficient kD and the standard rate coefficient k°.
The coverage of NIH/3T3 fibroblast cells on the substrate modified by the linker containing both cyclic (–RGDfK–) and linear KKK is, surprisingly, significantly better than the summation using one of them, which reveals the strong cooperativity of specific and non-specific cell adhesions.
During the dry season, the tracks in HGA were cyclic and linear (Fig. 6).
We report the molecular basis for the differences in activity of cyclic and linear antimicrobial peptides.
We used LEMONS to generate libraries consisting in equal parts of cyclic and linear hybrid natural products with 4 15 monomers.
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