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Both core and attachment proteins are equally necessary for complexes to function.
The remaining 791 subunits are present in both core and attachment proteins.
Thus, we calculated protein complex number in both core and attachment proteins.
This small component is also merged into the single giant component if we consider both core and attachment proteins.
We have not considered those 791 proteins for evolutionary rate analyses due to their presence in both core and attachment proteins.
We have obtained a similar proportion of essential proteins in both core and attachment proteins suggesting that core proteins execute higher multifunctionality, whereas attachment proteins have a higher protein complex number.
Similar(54)
Therefore, 790 proteins are used as both cores and attachments.
In fact, as mentioned in the 'Methods' section, 790 proteins among the total number of 1,491 proteins act as both cores and attachments.
In contrast, both the core and attachment proteins are used in function assignment of complexes.
As many genes are present both in cores and attachments, and because we observe no significant difference between the fraction of genes unique to cores and the fraction of genes unique to attachments that lead to a strong negative fitness effect upon deletion, we conclude that, in general, core and attachment components are equally important for the complex cellular machinery.
Surprisingly, we observed a similar proportion of essential genes in core and attachment proteins (two-sided Fisher's exact test, Core: 38.66%, Attachments: 34.51%, P = 2.7 × 10−).
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