Sentence examples for both contractile dysfunction and from inspiring English sources

We previously demonstrated in MD murine models that MAO-dependent oxidative stress is causally linked to both contractile dysfunction and cell death [11].

The volume-sensitive chloride channel inhibitors IAA-94 and DIDS prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3K, Akt and Erk 1/2.

To test this hypothesis directly, a second series of experiments was conducted in mechanically ventilated rats continuously infused with 1 mg/kg/h R548, the prodrug of a selective JAK1/JAK3 inhibitor, R507 (Supplemental Fig. S1 and ref. 21), for the duration of the ventilation period and then assessed for both contractile dysfunction and atrophy.

Furthermore, reasons for the significant transient elevation of IL-6 mRNA are not possible to discern; however, the dual association of IL-6 with both contractile dysfunction [43] and cardioprotection [44] is intriguing and worthy of further investigation.

Alcohol intake is associated with myocardial contractile dysfunction and apoptosis although the precise mechanism is unclear.

Chronic excessive drinking leads to myocardial contractile dysfunction and dilated cardiomyopathy, where ethanol toxicity plays an essential role.

For instance, Cr loading in utero was found to markedly attenuate hypoxia-induced contractile dysfunction and fiber atrophy of the diaphragm muscle in the spiny mouse [72, 73].

The consequences of ischemia can be described as contractile dysfunction and stunning, arrhythmia and infarction each representing different endpoints of injury.

Mutations in MYBPC3 can cause hypertrophic cardiomyopathy that is characterized by cardiac hypertrophy, myocyte disarray, contractile dysfunction and sudden death.

Ventricular arrhythmias, contractile dysfunction, and Ca2+ overload is triggered as part of that pathology.

These phosphoinositide derivatives appear to promote calcium leak, contractile dysfunction, and protein catabolism.