As shown in Table 5, MGMT activity was inversely correlated with PFS in both dichotomous and continuous regression models in each of the three AG diagnoses.
However, MGMT was significantly inversely associated with PFS in both dichotomous and continuous regression models regardless of intervening progression after RT (Table 5).
However, as shown in Table 2, intervening recurrence had no effect on the association of MGMT with PFS in both dichotomous and continuous regression models.
In accord with our results for GBM, we found that MGMT activity is inversely associated with response to alkylating agent therapy in AGs, regardless of diagnosis and clinical course, in both dichotomous and continuous regression models (Table 5).
Restricting the analysis to the 69 newly operated or previously biopsied GBMs (median activity 5.4 fmol/10 cells, i.e., ~ 3250 MGMT molecules/cell) produced HR comparable to that observed for all 91 tumors in both dichotomous and continuous regression models (Table 2), and revealed a ≥ 6.3-fold (i.e., 1.033 57 0.25)) increase in risk of progression between the lowest and highest MGMT activity.
Logistic regression models reported a significant association of odds of walking with density of street trees and street-level betweenness (a measure of street network connectivity), while sensitivity analyses with continuous regression models for participants doing some walking indicated beneficial associations of distance walked with NDVI greenness and street trees.
E-R results are presented as categorical models and continuous regression models.
The continuous regression models do not have a conventional E-R pattern.
The authors reported that results were robust and consistently positive for categorical and continuous regression models.
Relationships of RA with baseline recorded characteristics, major cardiovascular risk factors, systemic inflammation and atherosclerosis were first investigated in multivariable logistic and continuous regression models as appropriate with consistent adjustment for demographic characteristics since age differed numerically by RA status.
