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As these modules include proteins both conserved and essential, this can give us a new insight for the research of biology evolution and conserved function modules.
Lipopolysaccharide (LPS) biosynthesis is an attractive antibacterial target as it is both conserved and essential for the survival of key pathogenic bacteria.
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The predicted secondary structure of SL1 consists of an upper stem with a GC-rich loop that facilitates dimerization, a lower stem, and an intervening bulge (G5, A24 G25 G26) that is both strictly conserved and essential for efficient packaging of the viral genome.
These data thus reveal a conserved and essential role for LKB1 in the proliferative responses of both thymocytes and mature T cells.
A complete structural and mechanistic understanding of this highly conserved and essential chaperonin remains elusive.
Magmas (mitochondria associated, granulocyte macrophage colony stimulating factor signaling molecule), is a highly conserved and essential gene, expressed in all cell types.
Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization.
TRiC/CCT is a highly conserved and essential chaperonin that uses ATP cycling to facilitate folding of approximately 10% of the eukaryotic proteome.
Wnt signaling proteins are highly conserved and essential for organismal patterning from nematodes to man [1] [3].
BAF is an abundant, highly conserved and essential protein in metazoans (reviewed by [13], [19]).
It is highly conserved, and essential for normal development of several organs including the brain, pancreas and the eye [16], [17].
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