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Cytotoxicity and pro-oxidative effect of both compounds were studied on human colon adenocarcinoma cell line SW 480.
For an understanding of this phenomenon, a new pentapeptide, RIIGLa was synthetized, and both compounds were studied by different physicochemical and biological methods.
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The structural, electronic and electrochemical characteristics of both compounds are studied in detail, and the feasibility in removal of two Li ions from the hypothetical Li2FeSiO3S is explored.
In order to analyse the interaction of piperine and SCT-66 with different GABAA receptor subtypes, receptors composed of different subunits were heterologously expressed in Xenopus oocytes and IGABA modulation by both compounds was studied by means of the 2-microelectrode voltage-clamp technique and a fast-perfusion system (see Section 2).
Base hydrolysis of both compounds was studied by Raman and NMR spectroscopies and showed that lactam ring opening is followed by fragmentation of the dioxothiazolidine ring leading to formation of the iminium ion within 3 min. The iminium ion slowly loses a proton and converts to cis-enamine (which is a β-aminoacrylate) in 1 h for sulbactam and in 4 h for 6β- hydroxymethyl) sulbactam.
Both the compounds were studied subsequently for the U2OS tumoricidal activity and it was found that L has LD50 value of 200 μM whereas the sodium analog cytotoxicity did not drop down below 60%.
The steric effects of the substituents L on the geometry and the energetics of the compounds were studied using both experimental and theoretical methods to clarify the effect of substituent position on complex behaviour and electrochemical properties.
The absorption and fluorescence emission of some of the prepared compounds were studied in dioxane, revealing that the substituents altered both the absorption and fluorescence emission maxima.
Hydrogen oxidation activities for the phosphide compounds were studied.
Antioxidant compounds were studied in perilla (Perilla frutescens (L).
Furthermore, the structure activity relationships of these compounds were studied.
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