At tmax – 20 years, CBATs for both compounds suggest that children at 5 years of age have greater body burdens than do either infants or adult women, consistent with previously reported PBDE biomonitoring studies (Sjodin et al. 2008; Toms et al. 2008, 2009).
Western blot results showed that pro-caspase-8, -9 and -3 were cleaved by the treatment of these compounds, suggesting that both extrinsic and intrinsic apoptotic pathways were activated.
Retroviral integrase enzymes have a nonspecific endonuclease activity that is stimulated by certain compounds, suggesting that integrase could be manipulated to damage viral DNA.
The DDS and HYD pathways in the HDS of the refractory sulfur-containing compounds were affected to a different extent by the nitrogen-containing compounds, suggesting that different active sites were involved in these two reaction pathways.
Collectively, these results demonstrate the models' ability to discriminate between active and inactive compounds, suggesting that the models may be used to pre-screen compounds to facilitate compound optimization and to design novel inhibitors for drug development.
The PK-C binding affinities for the new compounds were weaker in comparison to those of the parent compounds, suggesting that the extra OH does not engage efficiently in hydrogen bonding at the receptor.
The PCA of this shortlist of 65 closely reflected the PCA of all 187 compounds, suggesting that much of the variation between varieties was captured with less, but more relevant data.
For the two soils tested, the concentration of butanol measured at the groundwater zone was higher than the other compounds, suggesting that the transport of butanol was less retarded.
However, we still observed significant differences in the overall chemical profiles and in several individual compounds, suggesting that insemination quantity causes changes in pheromone production within days.
Crenation is indicative of a disturbance in the RBCs' membrane, an effect often observed for amphiphilic compounds, suggesting that the peptide might partially partition in the lipid bilayer [15], [16].
