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However, although its genome encodes a putative uronate isomerase sharing 28% identical amino acids with UxaC from E. coli, both compounds did not support growth as sole carbon sources at 50 mM (data not shown).
More importantly, both compounds did not affect the formation of other types of cytoplasmic protein aggregates or RNA granules, suggesting that these two compounds were highly SG-specific and could be used to modulate SG formation in the cells without modifications of the other types of cellular bodies.
Both compounds did not alter LT-induced changes of the cytoskeletal or microtubule network in 2D conditions (data not shown).
In fact both compounds did not show significant differences in Hb levels, in erythrocytes number, and in expression of VEGF.
Interestingly, both compounds did not reduce proliferation of intestinal epithelial cells, but rather, increased the fraction of Ki-67-positive intestinal epithelial cells.
Both compounds did not exhibit toxicity in vivo at the concentrations used and yet showed definite antitumor effects in syngeneic mice.
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However both compounds do not exert any significant effect on oxidative burst of phagocytes.
A chemical interaction between both compounds does not exist mainly because of treatment with alginate also did not alter viscopearls dimensions [74].
Small animal PET imaging studies indicated that both compounds do not accumulate in tumors and exhibit poor pharmacokinetics, clearing from the blood pool very rapidly and getting metabolized over.
Moreover, both of these compounds did not compete with [H]-7OH-DPAT for the binding site of dopamine receptors as well as with [H]-8OH-DPAT and [H]-ketanserin for the binding site of 5-HT1A- and 5-HT2A respectivelyespectively.
Both crude extract and isolated compounds did not cause significant behavioral and physiological changes in the animals within the tested doses (data not shown).
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both studies did not
both feet did not
both compounds were not
both strains did not
both countries did not
both promoters did not
both companies did not
both patients did not
both processes did not
both disciplines did not
both phases did not
both parties did not
both groups did not
both kidneys did not
both cytokines did not
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