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Lathyrism induced by BAPN affects both components of bone [ 18- 21].
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Transcriptional control of Runx2 and Sp7 is mediated via cell signaling including by the Wnt and bone morphogenetic protein (BMP) pathways, both central components of bone developmental regulatory networks (Long, 2012).
Quantitative analysis of bone development in both components of the scapula is presented below.
All of the other components of bone, organic and inorganic, are of course also essential for bone integrity, but the importance of availability of structural materials is most easily illustrated by consideration of calcium balance (dietary intake versus excretory output).
However, the major metabolic activity in bone is carried out by osteoblasts, which generate the protein matrix, and osteoclasts, which are large multinucleated cells that digest and dissolve the components of bone.
Basic components of bone fibrils are collagen, mineral and water.
Other organic components of bone may be bound to fibrils and exert additional effects.
The major components of bone tissue engineering are the scaffold, cells, and growth factors.
Bone architecture and mineralization are generally considered to be important components of bone quality, and determine bone strength in conjunction with bone mineral density.
Direct measurement of these components of bone strength may result in improved fracture risk prediction or therapeutic monitoring.
Osteoblasts are located on bone surfaces and are the cells responsible for bone formation through secretion of the organic components of bone matrix.
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