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Companies such as Illumina and Affymetrix have already designed chips including both common and low frequency variants discovered in the 1000 Genomes Project [ 5].
To test for association of both common and low frequency alleles with the disease and the task of moving from confirmed association signal to complete enumeration of the pattern of causal variants at a given locus presents great challenges [ 3].
The power for testing association of both common and low frequency alleles in the CEU and CHD was plotted in Additional file 8, Figure S6 and Additional file 9, Figure S7.
Additional effort to identify both common and low frequency genetic variation in this species is warranted, based on the potential opportunity for and significance of developing new genetic models of human disease.
With the completion of the whole genome sequencing, now it is time to evaluate the power for testing the association of both common and low frequency alleles with the disease under different study designs and disease scenarios.
To evaluate the genotyping efficiency of the tagging approach to both common and low frequency SNPs, we used pair-wise methods in which every allele was captured by a single tag at the prescribed r2 threshold [ 10] to select tag SNPs from the low coverage pilot dataset.
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These categories were dichotomised into "high" (fairly common and very common) and "low".
In this study, we report a prospective study for molecular diagnosis of PSA-screened patients who are scheduled for diagnostic biopsy (prebiopsy cohort) using a novel panel of both common TMPRSS2 ERG subtypes and low-prevalent TMPRSS2 ETS (ETV4, ETV4, and ETV5) fusion markers.
Both the frequencies (rare vs. common) and densities (low vs. high) of the RE tactics were manipulated in large enclosed populations, where their relative survival and breeding success were monitored over the breeding season.
Hypertension is common in both developed and low- and middle-income countries [1].
Delay in the start of TB treatment is relatively common both in high and low TB prevalence countries [ 14- 19].
More suggestions(15)
both common and troublesome
both common and strain-specific
both common and Legionella-specific
both common and unusual
both common and far-reaching
both quantifiable and low
both developed and low
both common and preferred
both common and different
both common and improvised
both common and metal-specific
both common and unwise
both controlled and low
both common and formal
both common and distinct
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