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We demonstrated that mutation of matrilin-3 and COMP caused changes in the extractability of other cartilage proteins and that proteomic analyses of Matn3 V194D, Comp T585M and Comp DelD469 mouse models revealed both common and discrete disease signatures that provide novel insight into skeletal disease mechanisms and cartilage degradation.
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Common and discrete intracellular pathways involved in the functional activity of single and various combinations of micronutrients need to be identified.
(A ) Structures of the antiandrogens bicalutamide (top), enzalutamide (middle), and ARN-509 (bottom) oriented to highlight the common and discrete regions of the molecules.
The common and discrete disease signatures that we have identified in this study might therefore explain these differences in the 'cartilage phenotype' of these genetic mouse models of PSACH-MED.
It is both common and highly destructive.
Salmonella is both common and potentially lethal.
Furthermore, raven 'haa' calls are described as common and widespread discrete calls (Pfister, 1988), which suggests that ravens in our study discriminated familiar from unfamiliar individuals based on learned individual cues, not by regional or group-specific differences or dialects.
Both continuous and discrete systems are considered.
Continuous relaxation training of discrete latent-variable models can flexibly capture both continuous and discrete aspects of natural data.
Introducing discrete step-functions resulted in a hybrid model containing both continuous and discrete variables.
Based on common concepts of computational logic and discrete mathematics, we formalize vignette specifications as abstract state machine (ASM) models [7, 14].
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