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Some of the people in the study who initially performed poorly on a memory and reasoning test showed improvement in both cognitive function and blood flow after imbibing.
Both cognitive function and BMD also depend on various nutrients in food.
We evaluated both cognitive function and brain MRI-detected lesinns in a large cohort of community-dwelling subjects.
These studies generally have found inverse associations between indices of lead exposure and both cognitive function and change in cognitive function (Shih et al. 2007).
Previous studies show that these transgenic mice display progressive neurodegeneration in the hippocampal and cerebellar regions and a decline of both cognitive function and motor skills from 6 months of age.
Another point worth considering is that the average age of patients in this cohort was approximately 62 years; associations with both cognitive function and brain findings might be stronger in an older cohort.
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In contrast, studies in animal models, including rodents and primates, clearly show that prenatal cocaine exposure has deleterious effects on the developing brain, affecting both cognitive functions and emotional responses [5], [6].
We have attempted to provide additional specificity to our findings by including measures of RD and AD, but the general point remains that optimal white matter integrity, as quantified by measures of FA, RD, and AD may underpin both cognitive functioning and clinical disease status.
The interaction tests to assess effect modification by age/period are statistically significant for both cognitive function (p=0.004) and education (p=0.003), consistent with higher mortality among men with better cognitive function or education when they experience unemployment at a later age.
Given that both impaired cognitive function and impaired mobility contribute to loss of functional independence which is associated with reduced quality of life, greater risk for institutionalization, and increased mortality – there is a critical need to further investigate the specific contribution of cognitive functioning and mobility to HRQoL and wellbeing.
Both impaired cognitive function and social isolation are prevalent concomitants of aging in industrialized nations [ 1, 2].
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