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Results from the in vitro cytotoxicity studies showed that blank NPs did not alter the viability of both cells lines, except for concentrations higher than 600 μg/mL.
Tzabcanin inhibits adhesion of both cells lines to vitronectin and exhibited very weak cytotoxicity towards A-375 cells; however, it had no effect on cell viability of A-549 cells.
Results (Figure 5) confirmed this hypothesis in both cells lines.
However, both cells lines have disabled apoptotic programs [30], incongruous to directly compare the results.
The CAIX expression of both cells lines were validated during the course of this study.
TGFβ treatment resulted in dissolution of cell-cell adhesion and increases in spindle-like projections in both cells lines (Figure S1).
Similar(21)
This was observed for both cell lines.
Both cell lines were incubated with Sgc8-FSNPs.
While nine of these were active against both cell lines.
Most compounds exhibited significant inhibitory activity on both cell lines.
Importantly, both cell lines express LRP-1.
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