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Moreover, Ni2+ disrupted cell proliferation in both cell types suggesting Ca2+ import through calcium release activated calcium channels (CRAC).
Addition of PI3K inhibitor (LY294002) in the presence of T attenuated these effects in myotube morphology (in both cell types) suggesting a role for the PI3K pathway in T stimulated hypertrophy.
The increase was similar in both cell types, suggesting that iPS cells have similar HRR capacity as ES cells.
This work also found that alpha-mannan formed the outer layer of both cell types, suggesting that these polysaccharides mediate surface interactions.
Nucleosomes are enriched at the tissue-specific HMRs (TS-HMR) boundaries in both cell types suggesting that nucleosome organization surrounding HMR boundaries is independent of methylation status.
However, E2F4 and p300 were not significantly associated with the STAT5 binding sites in both cell types suggesting that only defined cell-specific co-TFs are related with STATs.
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The fact that we find increased membrane GluR1 following PGE2 on both cell types suggests that glutamatergic signaling in both neurons and glia may be relevant for the organization of sex differences in the POA and adult male sex behavior.
However, phenotypic results in both cell types suggest that hypoxia does not significantly increase either cell number or migration and, in addition, enhances tumour cell apoptosis.
Concerted mathematical and experimental analysis of global binding patterns for 10 key haematopoietic TFs in both cell types suggests that cell type-specific binding is not opportunistic, but instead makes meaningful contributions to cell type-specific transcriptional control.
The reduction in apoptosis due to inhibition of GSK3 in both cell types suggests that p53 is one of several proapoptotic targets of GSK3, consistent with the identification of other GSK3 targets including MITF and USF1, Mcl-1 and eIF2B.
We observed mostly non-overlapping localization of these two proteins in both cells types, suggesting that mouse Mbd5 does not bind heterochromatin in cultured cells (Fig 8C and Supplementary Fig S6).
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