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However, phenotypic results in both cell types suggest that hypoxia does not significantly increase either cell number or migration and, in addition, enhances tumour cell apoptosis.
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Moreover, Ni2+ disrupted cell proliferation in both cell types suggesting Ca2+ import through calcium release activated calcium channels (CRAC).
Addition of PI3K inhibitor (LY294002) in the presence of T attenuated these effects in myotube morphology (in both cell types) suggesting a role for the PI3K pathway in T stimulated hypertrophy.
The increase was similar in both cell types, suggesting that iPS cells have similar HRR capacity as ES cells.
The fact that we find increased membrane GluR1 following PGE2 on both cell types suggests that glutamatergic signaling in both neurons and glia may be relevant for the organization of sex differences in the POA and adult male sex behavior.
Nucleosomes are enriched at the tissue-specific HMRs (TS-HMR) boundaries in both cell types suggesting that nucleosome organization surrounding HMR boundaries is independent of methylation status.
This work also found that alpha-mannan formed the outer layer of both cell types, suggesting that these polysaccharides mediate surface interactions.
Concerted mathematical and experimental analysis of global binding patterns for 10 key haematopoietic TFs in both cell types suggests that cell type-specific binding is not opportunistic, but instead makes meaningful contributions to cell type-specific transcriptional control.
However, E2F4 and p300 were not significantly associated with the STAT5 binding sites in both cell types suggesting that only defined cell-specific co-TFs are related with STATs.
The effects of osmotic stress using sorbitol were also inhibited significantly, but not completely, by STO-609 in both cell types, suggesting that in this case the effect is only partially mediated by CaMKKs.
Importantly, upon stimulation with the adenylyl cyclase activator, Forskolin, all PDE4D isoforms show the same increase in activity in both cell types, suggesting that loss of one βAR subtype or the other has not perturbed overall cAMP signaling.
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