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Both cell types produced increased IL6 secretion, measured by ELISA, when incubated for 24 h with standard PS or R3N+ beads.
Both cell types produced subcutaneous tumors within the same time frame (Fig. 4A).
After 2 months, both cell types produced histologically and macroscopically equivalent hyaline-like cartilage repair tissue within porcine femoral trochlea chondral defects.
Both cell types produced significantly higher MP numbers than in resting conditions and a dose-dependent increase of MP production was observed (Fig. 3).
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Both cell types produce smaller tumors with larger latency periods than untreated cells, indicative of smaller proliferation capacity.
Both cell types produce a wide array of soluble inflammatory mediators (cytokines, chemokines) which are critically important in the initiation and perpetuation of the disease.
Although the exact mechanisms whereby CD4 T-cells drive CNS autoimmunity are not well understood, both cell types produce GM-CSF (granulocyte/macrophage colony-stimulating factor), a key cytokine required for the initiation of disease (El-Behi et al. 2011; McQualter et al., 2001; Ponomarev et al., 2007).
However, the cell types produced using this approach are predominantly fetal-like in phenotype and function, limiting their use in regenerative medicine.
The complex spectrum of cell types produced in mammalian hematopoiesis can be understood as the output of highly combinatorial transcription factor action.
While environmental factors could influence the relative proportions of the different cell types produced, these signals could not induce the RPCs to generate temporally inappropriate cell types [20], [21], [22].
We quantitatively compared the cell types produced by neurospheres in the GSI-treated group with that of the control.
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