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We found that both cell types have similar antiviral and pro-inflammatory responses.
Both cell types have been described to have different properties that may play a role in regeneration.
Both cell types have stereocilia projections arranged in bundles but the shape and arrangement of the bundles is different in the two systems [35], [36].
It is interesting that two different types of cells (fibroblasts and smooth muscle cells) exhibit similar threshold stresses for Rac activation, suggesting that the setpoint for the enzyme activation is the threshold strain (deformation), since both cell types have similar softness (or its inverse, stiffness).
Furthermore, analysis of cell proliferation by 3H-thymidine uptake revealed that both cell types have a similar responsiveness to MPA or growth factors such as FGF-2 [41], and both display similar sensitivity to the inhibitors PD98059 and LY294002, as shown here (Figure 2C).
What is certain, however, is that IPSC and ESC mitochondria are very similar to each other, and all indications are that both cell types have low oxidative phosphorylation and ROS generation, producing in an intracellular environment conducive to the preservation of genomic integrity.
Similar(39)
The paucity of both cell types has hampered molecular and cell biological studies, which often require large quantities of purified cells.
After 1 day in culture, both cell types had spread and coalesced on the fibres to form a cell layer, which conformed closely to the underlying topography.
Under the submerged culture, IL-13 treatment in both cell types has minimal effects on viral load, IP-10 and Mx1.
Furthermore, both cell types had their own unique miRNA signal distribution pattern suggesting that each cell type had a unique RISC miRNA profile.
Interestingly, both cell types had increased viability in the presence of NEC-1, however, there was little protection with zVADfmk (Fig. 5C,F).
More suggestions(18)
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