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However, evaluating changes in epigenetic patterns from one generation to the next must be interpreted cautiously because such marks are both cell specific and malleable.
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A key advantage of the Csf1r-Mer-iCre-Mer mouse is that it permits both cell-specific and temporal control of Cre-mediated recombination.
These data demonstrate that sleep loss after inhibition of DPM activity is both cell-specific and independent of the particular method used to suppress DPM activity.
Maturation of neural precursors is tightly regulated by both cell specific, intrinsic and extrinsic factors (Berger-Sweeney and Hohmann, 1997; Cameron et al., 1998; Pomeroy and Kim, 2000; Nguyen et al., 2001; Sauvageot and Stiles, 2002).
First, we assessed the response of CD83Tg (founder 2) and wild-type spleen cells to both, T cell specific and B cell specific stimulation.
In this report we demonstrate that the herpes simplex virus type 1 reiteration element 1 (RE1) (nt: 117158 117353) in concert with its flanking sequences is both a cell specific and stimulus inducible regulatory domain.
The expression of both genes is B cell specific and both CD79 molecules have a single extracellular Ig domain, a transmembrane (TM) region and a cytoplasmic tail (CYT) containing an immunoreceptor tyrosine-based activation motif (ITAM) [19].
Expression of CYP3A genes is both tissue and cell specific and exhibits inter-individual variation [11].
These experiments suggest both β-cell specific and non-β-cell tissue specific effects involving the ZnT8 gene and type 2 diabetes risk [ 60].
The luminal interaction maps were built using both cell-specific genes and interpolated genes [see Additional files 12 and 13].
For a sliding window of width 20, both cell-specific regions and non-specific regions have a median width of 23 methylcytosines.
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