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The nature of the extracellular matrix interactions with cultured hepatocytes determines both cell shape and cytoarchitecture which, in turn, are related to the expression of transcription factors and gene programs (Ingber, 1993; Nagaki et al., 1995; Rana et al., 1994).
The morphogenesis of a developing epithelium is associated with the control of both cell shape and cell contacts.
Most importantly, it had been shown that EpiC (Epc1p, gene: EPC1) influences both cell shape and the fidelity of cortical development (Huttenlauch et al., 1998).
Both cell shape and cell area were found to vary only marginally during the experiment.
dLRCH protein localizes to cortical regions undergoing contraction and depletion of dLRCH consistently provokes defects in both cell shape and positioning of the spindle during mitosis.
Previous studies analyzing cell functions in response to both cell shape and surface area of adhesive contact were, to the best of our knowledge, exclusively limited to engineered 2-D surfaces.
Similar(47)
Functional assays in cultured cells have been proven as an efficient means of identifying the molecular pathways involved in the control of both cell shape [40] and division [41], [42].
To quantitate these changes, we measured both the cell shape and cell area using the OpenLab software program.
In Dictyostelium, the full-width at half-maximum size of actin waves on flat surfaces is ∼1 μm and protrusions are ∼1.5 μm wide as measured from both the cell shape and the cell footprint.
This is a case in which a number of assumptions on the type of the cell dynamics (both for the cell shape and for the cell overall displacement) is needed and taken into account by solving the propagator equation for a smooth function [7], [15].
Interestingly, cell seeding density influenced differentiation through both changes in cell shape and non-shape-mediated effects: density-dependent adipogenesis and chondrogenesis were regulated primarily by cell shape whereas non-shape effects strongly influenced osteogenic potential.
More suggestions(15)
both cell growth and
both cell type and
both cell viability and
both cell density and
both cell apoptosis and
both cell adhesion and
both strip shape and
both cell delivery and
both cell wall and
both cell death and
both pit shape and
both cell positioning and
both cell surface and
both cell culture and
both cell adherence and
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