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In our previous studies we noted that dopaminergic neuroblastoma cells (SH-SY5Y) die mostly via apoptosis after exposure to 6-OHDA (≤100 μM) but African green monkey fibroblast (CV1-P) cells do not succumb, although in both cell lines there were increased intracellular p53 levels.
In both cell lines there was a tendency towards a lower sensitivity to digoxin than to the other two CGs.
In both cell lines there was down regulation of activity by hypoxia, to a similar extent to that induced by mimic-210 or by ISCU depletion.
In general, our data show that in both cell lines there is a prolonged induction time in 5-Aza-CR treated cells as compared to 5-Aza-CdR treated cells.
In both cell lines there was a higher copper efflux in cells pre-treated with aRA at 4 h.
In contrast, although indomethacin tended to show concentration-dependent inhibition in both cell lines, there was no statistically significant difference and 4(d)).
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Notably, although a considerable number of tags were found in both the MCF-7 and MDA-MB-231 cell lines, there was a significant higher LINE-1 demethylation level in MDA-MB-231 compared to MCF-7.
Unlike cell lines, there were specific decreases in both Syk/ZAP-70 and Lyn/Lck phosphorylation in ZAP-70+ CLL cells after 1 h of gefitinib treatment.
Despite recent work in rodent tissue or cell lines, there is a paucity of literature concerned with the culture of human muscle derived cells (MDCs) in engineered constructs.
Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.
Though there are few studies on cytotoxicity of nanoparticles on mammalian and human cell lines, there are hardly any reports on genotoxic and cytotoxic behavior of nanoparticles in plant cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com