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Intracellular ROS generation in both cell lines increased by hyperthermia treatment and decreased by N-acetyl-L-cysteine (NAC) treatment.
In both cell lines, increased [Ca2+]o and/or NPS R-467 reduced doubling time values.Treatment with NPS R-467 down-regulated CaSR mRNA expression in both cell lines.
Furthermore, both cell lines increased mtDNA copy number by twofold or more.
We also determined that silencing IGFBP-2 in both cell lines increased the sensitivity of the cells to docetaxel.
In both cell lines, increased p38 activity was demonstrated following vinorelbine but not doxorubicin treatment, whether vinorelbine was given prior to or simultaneously with doxorubicin.
Results showed that Cd uptake by both cell lines increased in a dose-dependent manner and its uptake by Caco-2 cells (720.15 µg mg−1 cell protein) was significantly higher than HL-7702 cells (229.01 µg mg−1 cell protein) at 10 mg L−1.
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Knocking down plakoglobin expression substantially increased the prometastatic potential of both cell lines, increasing proliferation, reducing intercellular adhesion, and increasing invasion.
For both cell lines, increases in BRCA1 levels of >2-fold were observed at the lowest dose of genistein tested (0.5 μ M); while similarly robust increases in BRCA2 levels required higher genistein doses (1 2.5 μ M).
Under hypoxic conditions, both cancer cell lines increased LRP1 expression by about 110% and 70%, respectively.
Transfection of Tmem176b into both microglial and macrophage cell lines increased apoptosis.
Cyclic stretch of human pulmonary epithelial cell lines increased both TLR2 mRNA and protein expression.
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