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In addition, both cell lines have comparable doubling times and sizes.
Unfortunately, there is data suggesting that both cell lines have undergone significant changes and/or selection in culture that distinguish them from the primary human retinoblastomas [100].
Both cell lines have advantages and disadvantages, which must be taken into account when choosing them as a model T cell line.
Both cell lines have been already used to develop several human vaccines [28], and Vero cells are currently used for candidate DEN vaccine production.
Though both cell lines have contrasting phenotypes and clinical prognosis [28] they showed an increase in their invasiveness behaviour that was dependent of XRCC3 over-expression.
It is of note, however, that both Jurkat E6.1 T cells and HuT78 T cells consistently produced substantially more IL-2 than APBTs upon treatment with similar concentrations of TCR antibody alone, suggesting both cell lines have increased expression of IL-2 upon TCR activation.
Similar(41)
Both cell lines had higher basal levels of autophagic activity than HEK293T cells, as demonstrated by the presence of a small number of eGFP-LC3 puncta in 30%40%% of cells expressing the empty vector (Fig. 2A and 2B).
Both cell lines had irregular nuclei of variable size.
Both cell lines had subpopulations in different passages.
Furthermore, both cell lines had a different sensitivity to AG1024 although both cell lines had similar expression level of IGF-1R.
By 48 h, ∼50% of the cells in both cell lines had committed to apoptosis.
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