Sentence examples for both cell cycle stage from inspiring English sources
Even in short-lived animals that do not develop tumors, such as C. elegans, both cell cycle stage and cell fate have been demonstrated to greatly affect DSB repair.
Because the major anti-Endos activity displays closely similar sensitivities to okadaic acid or fostriecin when comparing M phase and interphase frog egg extracts, it appears that the same phosphatase is responsible for this activity during both cell cycle stages.
Therefore, it is surmised that PTEN protein localization may be dependent on both the cell cycle stage and the differentiation stage.
Therefore, we conclude that in human cells both NHEJ and HR are required, with cell cycle stage specificity, for the repair of Top2-mediated reversible DNA damage.
Cell cycle stage was confirmed by FACS for both siControl and siTim transfected cells (data not shown).
Ki67 is only a marker for "cycling cells" and does not tell in which cell cycle stage the cells are.
Following culture, the cells were fixed and processed for immunofluorescence as described below to confirm cell cycle stage.
To investigate this possibility, we analysed the dynamics of H3K9ac-mintbody-GFP during each cell cycle stage.
We show that the rates of DSB repair depend on the cell cycle stage at the time of damage.
In line with these results, our data confirmed that the acetylation status of histone H3 at K9 remains constant irrespective of cell cycle stage in proliferating plant cells (Fig. 4c).
Thus, it is important for researchers to examine whether N-or C-terminal conjugation of Geminin/Cdt1 degron works for efficient degradation of the target protein in the expected cell cycle stage.
