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Our results indicate a strong correlation between mitochondrial biogenesis and cell cycle control and suggest that some proteins could have a double role: for instance in controlling both cell cycle progression and mitochondrial functions.
We have established a unique model system for studying cardiac cell cycle progression, and show in contrast to previous reports that Rb actively regulates both cell cycle progression through the G1 checkpoint and maturation of heart cells.
In addition, a prior report demonstrated that overexpression of FIP200 in breast cancer cells resulted in an inhibition of both cell cycle progression and clonogenic cell survival due to FIP200 promotion of p21 expression [7].
Conceptually, a dual role for pRb as a regulator of both cell cycle progression and adherens junction assembly could be of central importance in the orchestration between cell proliferation and cell adhesion, an orchestration that may be pivotal for tissue morphogenesis.
In our model, we consider both cell cycle progression and cell death after irradiation.
These results confirm that PFKFB3 expression is required for both cell cycle progression and maintenance of an antiapoptotic state.
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E2F1, the founding member and best-characterized of the family, has a unique role compared with other E2Fs, showing characteristics of being both an oncogene and a tumor suppressor, as it is able to induce both cell-cycle progression and apoptosis.
CHK1 participates in this response by both delaying cell cycle progression and participating in DNA repair.
CLB1 and CLB2 both promote cell cycle progression into mitosis and their transcripts accumulate during G2 and M.
Emerging findings suggest that deregulation of cell cycle components such as CDK2 axis has the potential to contribute both to cell cycle progression and to endocrine resistance [ 11].
Thus, consistent with earlier genetic analysis, these data strongly indicate that Clp1p mediates a survival advantage upon LatA treatment through both delaying cell cycle progression and by stabilizing the actomyosin ring.
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