Sentence examples for both cell cycle exit from inspiring English sources

Overexpression of p27Xic1, a Xenopus homolog of p27Kip1, in Xenopus retina glial progenitor cells promotes both cell cycle exit and differentiation [ 50].

The zinc finger transcription factor KROX20 is a key regulator of Schwann cell differentiation, regulating both cell cycle exit and the gene expression that drives myelination (Topilko et al., 1994; Zorick et al., 1999; Parkinson et al., 2004, 2008).

It has been shown that RB protein (pRb) is responsible for a major G1 checkpoint (restriction point) blocking S-phase entry and cell growth, promoting terminal differentiation by inducing both cell-cycle exit and tissue-specific gene expression (Weinberg, 1995).

Brain size was restored to only 78% of control values, suggesting that progenitor pool depletion by both premature cell cycle exit and apoptosis contribute to this phenotype.

In both cases progenitor proliferation, cell cycle exit and production of neuronal precursors appeared undisturbed, but the postmitotic precursors lost their GABAergic identity and acquired glutamategic characteristics instead.

Both DNA damage and premature cell cycle exit persist in the Cre+, Rest GTiGTi, Trp53 fl/fl mice, indicating that these events can occur independently of activation of the apoptotic pathway.

Activation of the tumor suppressors encoded by this locus leads to an irreversible cell cycle exit.

We also demonstrated that Sox3 had similar effect in NSCs as in glioma cells and and block cell cycle exit, whereas its dominant negative version promote cell cycle exit in both NSCs and glioma cells.

We postulate that this role is to inhibit cell cycle progression and promote cell cycle exit.

Altogether, these findings are suggestive of reduced proliferation, premature cell cycle exit and induction of differentiation.

Conversely, overexpression of CBF slows cell cycle exit and delays muscle differentiation.