Sentence examples for both cell cycle block from inspiring English sources

Under these conditions, cells switch on the senescence program and express markers related to both cell cycle block and growth stimulation.

p53 is up-regulated by DNA damage and has been shown to be associated with cell cycle block both in G0/G1- and G2/M-phase depending on the nature of damage, dose and cell type (Lu and Lane, 1993).

Treatment of both with the ErbB2-specific antibody trastuzu-mab caused a cell cycle block that was accompanied by a decrease in PI3K/Akt pathway activity, and by downregulation of Myc and D-type cyclins [ 55].

WEE1 kinase in higher plants is transcriptionally up-regulated in response to both DNA replication and DNA damage checkpoints and it couples the cell cycle block in response to DNA damage with DNA repair [14] (Fig. S1).

Furthermore, while p53 was induced in 70Z/3 cells by declopramide, neither the apoptotic mechanism nor the G2/M cell cycle block were dependent on p53 activation since both effects were also seen in p53 deficient HL60 cells after addition of declopramide.

NOSH-sulindac inhibited cell proliferation, induced apoptosis, and caused G2/M cell cycle block.

NO-ASA inhibited the growth of BxPC-3 cells (IC50 = 13 μM), by inhibiting proliferation modestly and inducing apoptosis, necrosis and G1/S cell cycle block.

VN and VS2 were the two most active compounds against A375 (IC50 of 4.7 and 2.6 μM, respectively), causing apoptosis and cell cycle block.

CALDOX cells had slower proliferation rate and an extended G1 cell cycle stage than the parental line, mainly due to an intrinsic activation of CDNK1 (p21), but this cell cycle block was not involved in the mechanism of resistance.

The analysis of the ploidy of minichromosomes in cells that are released from arrest demonstrates that the sister molecules are properly segregated when the cell cycle block is removed.

Cells were fixed one day after applying the cell cycle block.