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Hence, the numbers of both, cell cycle arresting and apoptotic pathways were reduced.
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Thus, by activating p53, normal cells have the ability to implement both cell cycle arrest and the induction of apoptosis.
In summary, both cell cycle arrest and apoptosis in HeLa cells have a clear p53-dependent component in the case of RPS9.
In subsequent validation experiments, 17-AAG alone or in combination with cisplatin inhibited lung adenocarcinoma cell proliferation and induced both cell cycle arrest and apoptosis.
Our study provides direct evidence that both cell cycle arrest and senescence, and apoptosis induced by nutlin-3a are due to activation of the p53 pathway.
The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis.
Consequently, TAp63s can induce both cell cycle arrest and apoptosis.
The effect of butyrate on cells grown in vitro is to drive both cell cycle arrest and apoptosis.
These results indicate that IL-1 β released by activated microglia induces both cell cycle arrest and apoptosis in NPCs.
Inhibition of tumor FAS causes both cell cycle arrest and apoptosis, indicating FAS is a promising target for cancer treatment.
The normal cellular response to DNA damage involves both cell cycle arrest and activation of DNA repair mechanisms.
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