Sentence examples for both cell cycle arrest from inspiring English sources

Thus, by activating p53, normal cells have the ability to implement both cell cycle arrest and the induction of apoptosis.

In summary, both cell cycle arrest and apoptosis in HeLa cells have a clear p53-dependent component in the case of RPS9.

Our study provides direct evidence that both cell cycle arrest and senescence, and apoptosis induced by nutlin-3a are due to activation of the p53 pathway.

In subsequent validation experiments, 17-AAG alone or in combination with cisplatin inhibited lung adenocarcinoma cell proliferation and induced both cell cycle arrest and apoptosis.

The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis.

Consequently, TAp63s can induce both cell cycle arrest and apoptosis.

Hence, the numbers of both, cell cycle arresting and apoptotic pathways were reduced.

To conclude, our study provides evidence that the EGFR-TK inhibitor gefitinib induces both cell-cycle arrest and apoptosis in NE gastrointestinal tumour cells.

Although the mechanism remains unclear, when used to treat drug-resistant cases of malignant myeloma, bortezomib has been shown to induce endoplasmic reticulum (ER) stress, which can trigger both cell-cycle arrest and cell death (Obeng et al, 2006).

Considering that p53, which is a critical determinant in controlling both cell-cycle arrest and apoptosis, usually has crosstalk with MAPKs, and the downstream regulator p21 is probably involved in G2/M arrest through the p53-dependent pathway, we detected p53 and p21 protein levels using western blot analysis.

Some authors have demonstrated that HDACis have a radiosensitizing effect on glioblastoma cells in vitro and in vivo [ 20- 23] and also seem to be associated with inhibition of glioma cell growth by both cell-cycle arrest and apoptosis [ 24- 26].