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This indicates that in both cases, the variant alleles have a higher affinity for their cognate binding protein(s) than their wild-type counterparts.
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In both cases the variants are distributed uniformly along the entire coding region and intronic sequences flanking each exon [ 108].
In both cases, the IRAK1 197 variants show significantly reduced levels of phosphorylation.
In both cases, the C15S variants bound slightly more weakly to PC/PG bilayers containing 50% PG (by 1.3- to 2-fold) and the C15S variants bound much more weakly (by 9.3- to 12-fold) to bilayers containing only 20% PG.
In both cases, the joint effect of the variants was non-significant (χ = 15.65, df = 11, and χ = 3.99, df = 6, resp .. Finally, the analyses on the polygenic risk scores also failed to show a significant association (P >.15).
In both cases, the rare copy-number variants were "not random.
In all cases, the variant was inherited with no bias between maternal versus paternal transmission (Table S6).
In some cases, the variants proved to be from familiar bacteria, like E. coli.
In all six cases, the variants segregated with the respective phenotypes.
In both cases a variant that includes the deployment of pico sites is also considered.
In each case, the variant is not clearly truncating when studied closely.
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